Abstracts Track 2025

Area 1 - Databases and Information Systems Integration

Nr:	323
Title:	Evolutionary Learning for Investigating the Oncogenic Mechanisms of Nutrient Deficiency in Lung Adenocarcinoma
Authors:	Yann-Lin Ho, Shinn-Ying Ho and Tzong-Yi Lee
Abstract:	Background: Deficiencies in nutrients are known to contribute to DNA damage and elevate cancer risk. Standard treatments for lung cancer include surgery, radiation therapy, and chemotherapy. While these drugs are effective in combating lung cancer, they come with considerable side effects, including nausea, vomiting, and hair loss. Optimizing dietary intake of vitamins and minerals could play a role in cancer prevention. However, the specific oncogenic pathways influenced by nutrient deficiencies are not well understood. This study introduces an evolutionary learning -derived method, EL-CoxPH, aimed at uncovering the roles of nutrients in the oncogenic processes of lung adenocarcinoma. Method: We obtained the gene expression profiles and corresponding clinical data from 493 patients from the TCGA-LUAD dataset of The Cancer Genome Atlas. Each profile included 1,535 miRNAs along with survival-related information, such as patient status and survival time. EL-CoxPH constructs a molecular nutrition network by leveraging an inheritable bi-objective combinatorial genetic algorithm (IBCGA). EL-CoxPH identifies a prognostic miRNA signature and develop a Cox proportional hazards model. The framework encompasses three key identification tasks: discovering a novel survival-associated miRNA signature with prognostic relevance, identifying hub genes targeted by this signature, and exploring pathways as well as nutrient and drug associations related to these hub genes. Results: EL-CoxPH identified a 15-miRNA signature and established a Cox proportional hazards model, achieving a concordance index (C-index) of 0.654. This performance surpassed that of established prognostic models, including Cox-LASSO, Cox-Elastic, and random survival forest, demonstrating the effectiveness of the proposed method in survival prediction. The identified 15-miRNA signature, ranked in descending order based on their main effect difference scores, included hsa-mir-582, hsa-mir-4661, hsa-mir-212, hsa-mir-4443, hsa-mir-29b-2, hsa-mir-548b, hsa-mir-29b-1, hsa-mir-5571, hsa-mir-132, hsa-mir-142, hsa-mir-584, hsa-mir-3130-2, hsa-mir-374a, hsa-mir-30e, and hsa-mir-548q. In addition to identifying prognostic miRNAs, EL-CoxPH identified six key nutrients—curcumin, quercetin, resveratrol, selenium, vitamin E, and zinc. These findings underscore the potential role of nutrient deficiencies in cancer progression, particularly through their regulatory impact on oncogenic pathways. Conclusion: This study introduces EL-CoxPH, an evolutionary learning-derived method that integrates machine learning and systems biology approaches to enhance the analysis of oncogenic mechanisms associated with nutrient deficiency. By constructing a molecular nutrition network, EL-CoxPH identifies key nutrients with potential protective effects and elucidates the oncogenic pathways influenced by nutrient deficiencies. Using lung adenocarcinoma as a representative model, the proposed method provides novel insights into the complex interplay between nutrient availability and cancer progression, offering a foundation for further research into targeted nutritional interventions in oncology.

Area 2 - Information Systems Analysis and Specification

Nr:	271
Title:	The Impact of Social Capital on Knowledge Integration in Support of Virtual Teams
Authors:	Ali Reza Montazemi
Abstract:	In organizations, actors use different kinds of formal and informal communication methods to enhance their decision-making processes. Informal communications provide critical channels for collective sense-making and shared understandings in support of complex decision problems (Lang, 2001; Lin et al., 2022). They are formed over time in form of organizational memory (transactive memory) by actors with a need to associate themselves with others who are experiencing similar issues and challenges (Nonaka and Toyama, 2003). Organizational memory extends beyond the individual’s memory to include other components such as organizational culture, production processes and work procedures, formal organizational structure, ecology (work setting) and information archives (Alavi and Leidner, 2001; Jin and Shao, 2022). Considering the distributed nature of organizational memory, an important process of knowledge management in organizational settings is the transfer of knowledge among the actors. This reflects the knowledge-based view of the firm, which depicts organizations as repositories of knowledge and competencies (Kogut and Zander, 1996). Because the acquisition and exploitation of knowledge are predominantly social processes, social capital is believed to be an important catalyst in managing knowledge resources (Jin and Shao, 2022). Central to this notion is that social capital influences the knowledge available for the focal actor through their network of relationships (i.e., structural component); the knowledge actually disclosed to, or retrieved by, the focal actor (i.e., relational component); and the efficiency of the resulting knowledge transfers and exchanges (i.e., cognitive component) (Montazemi et al., 2008). Notwithstanding its importance to facilitate the use of knowledge for functional purposes, there is little known about its dysfunctional effects that encourage organizational members to abstain from reﬂection, thinking beyond instrumental concerns or asking critical questions about the reasons for organizational practice (Alvesson and Spicer, 2012; Jin and Shao, 2022). This is referred to as functional stupidity. Functional stupidity is the inability and/or unwillingness of the actors to use their cognitive and reﬂective capacities in anything other than narrow and circumspect ways (Alvesson and Spicer, 2012). In this paper, we examine the impact of social capital on knowledge integration between teams (units) with high social capital working in real organizational settings of fixed-income (FI) financial firms. Eleven financial firms participated in this investigation that was completed in two phases. Our findings provide support for relational conceptualizations of coordination as an emergent phenomenon highly dependent on the quality of the relationships across units and individuals and on the presence of transactive memory processes. Both formal and informal communication structure are enacted towards knowledge management within these FI financial firms. The basic premise of their knowledge management is organizational compliance with a set of rules and procedures based on trust and normal market functioning. Such a premise provides a sense of certainty that allows FI financial firms to function smoothly. This can save the firm and its members from the frictions provoked by doubt and reﬂection on their decisional processes. However, deviation from such premise can result in functional stupidity.